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She won the 2013 Golden Globe and the 2012 Golden Globe for Best Actress in a Television Series for her performance.
Her first leading role on the big screen came in 1996, when she portrayed Juliet in the film Romeo Juliet, as well as Jenny in Oliver Stone's noir U Turn.
Danes' mother was born in Elizabeth, New Jersey, in 1945 and has a Bachelor of Fine Arts degree in painting and education from the Rhode Island School of Design (1967), an Associate of Applied Science in textile design from Fashion Institute of Technology (1971), a master's degree in early childhood education from Hunter College (1987), and a Master of Fine Arts from Otis College of Art and Design (2002).
During Danes' childhood her mother ran a small toddler day-care center called Danes Tribe out of the family's So Ho loft to supplement her work as a painter and textile designer, and later served as Danes' manager.
She made her film debut the same year in Little Women (1994).
Her other films include Home for the Holidays (1995), Romeo Juliet (1996), The Rainmaker (1997), Les Misérables (1998), Brokedown Palace (1999), The Hours (2002), Terminator 3: Rise of the Machines (2003), Shopgirl (2005), Stardust (2007), and A Kid Like Jake (2018).